Long-term ingestion of ammonium inhibits lysosomal proteolysis in rat liver |
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| Authors: | V Felipo M D Mi?ana R Wallace S Grisolía |
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| Affiliation: | Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Spain. |
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| Abstract: | A standard diet was supplemented with ammonium acetate (20%, w/w). The effect on liver protein degradation of oral administration of the ammonium diet to rats for 6 weeks has been studied. It is shown that lysosomal proteolysis is markedly decreased (by 62%) while non-lysosomal proteolysis is inhibited by 11%. This is the first report showing that ammonium ingestion inhibits liver proteolysis. |
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