Activity of some bromomethylated aromatic hydrocarbons on the in vitro synthesis of DNA and RNA |
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| Authors: | P Daudel F Gachelin M C Delcey P Jacquignon N P Buu Hoi P Queval |
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| Institution: | 1. Fondation Curie, Institut du Radium, Laboratoire Curie, ParisFrance;2. Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-YvetteFrance;3. Centre de recherches sur la Cancérisation Chimique et Hormonale, VanvesFrance |
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| Abstract: | The effect of a series of bromomethylated polycyclic hydrocarbons on in vitro DNA and RNA synthesis has been studied by measurement of the incorporation of 3H]-dTMP or 14C]-AMP into new chains. The inhibition of RNA synthesis was less than 12% for 9-bromomethylanthracene, 9-methyl-10-bromomethylanthracene and 12-bromomethylbenzo(a)acridine, and more than 37% for 7-bromomethylbenzo(a)anthracene, 7,12-dibromomethylbenzo(a)anthracene and 7-bromomethylbenzo(c)acridine. Analogous results were found for the inhibition of DNA synthesis, except for 7-bromomethylbenzo(c)acridine which had little effect. Apart from this exception a good correlation was found between the inhibitory action of the bromo derivatives and the carcinogenicity of the non-halogenated parent hydrocarbons. |
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| Keywords: | AMP adénosine monophosphate ATP adénosine triphosphate dTMP thymidine monophosphate dTTP thymidine triphosphate PCA acide perchlorique POPOP 1 4-bis-2(5-phényloxazolyl)-benzène PPO 2 5-diphényloxazole TCA acide trichloroacétique Tris trishydroxyméthylaminométhane |
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