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Synthesis and DNA binding ability of cyclam-amino acid conjugates |
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| Authors: | Venkata Ramana A Watkinson Michael Todd Matthew H |
| Affiliation: | aSchool of Chemistry, University of Sydney, NSW 2006, Australia bThe Walter Besant Building, School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK |
| Abstract: | N-Substituted cyclam–amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam–peptide conjugates could interact with DNA in a highly selective manner. |
| Keywords: | Cyclam Tetraazamacrocycle DNA binding Sequence selectivity |
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