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4-(4-alkylpiperazin-1-yl)phenyl group: a novel class of basic side chains for selective estrogen receptor modulators |
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| Authors: | Watanabe Nobuhide Nakagawa Hiroshi Ikeno Akihisa Minato Hisao Kohayakawa Chie Tsuji Jun-ichi |
| Affiliation: | a Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki-cho 33-94, Suita, Osaka 564-0053, Japan b Pharmacology & Microbiology Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki-cho 33-94, Suita, Osaka 564-0053, Japan |
| Abstract: | In the structure–activity relationships of spiro[indene-1,1′-indane] series, the 4-(4-alkylpiperazin-1-yl)phenyl group was found to be functionally equipotent to the 4-(1-piperidinoethoxy)phenyl group, the most widely used basic side chain in selective estrogen receptor modulators. |
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