Isolation of clustered genes that are notably homologous to the eicosapentaenoic acid biosynthesis gene cluster from the docosahexaenoic acid-producing bacterium Vibrio marinus strain MP-1 |
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| Authors: | Mika Tanaka Akio Ueno Kosei Kawasaki Isao Yumoto Satoru Ohgiya Tamotsu Hoshino Kozo Ishizaki Hidetoshi Okuyama Naoki Morita |
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| Affiliation: | (1) Bioscience and Chemistry Division, Hokkaido National Industrial Research Institute, AIST/MITI, Toyohira-ku, Sapporo, 062-8517, Japan;(2) Laboratory of Environmental Molecular Biology, Graduate School of Environmental Earth Science, Hokkaido University, Kita-ku, Sapporo, 060-0810, Japan |
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| Abstract: | A 40-kbp DNA fragment was isolated from the cosmid library of Vibrio marinus strain MP-1. Among the 22 putative open reading frames (ORFs) in this fragment, ORFs 8, 9, 10 and 11 had high homology with ORFs 5, 6, 7 and 8 of the eicosapentaenoic acid biosynthesis gene cluster, respectively. Then, we speculate that these ORFs are responsible for docosahexaenoic acid biosynthesis in this bacterium. |
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| Keywords: | DHA biosynthesis gene cluster docosahexaeboic acid eicosapentaenoic acid gene cloning Vibrio marinus |
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