Deactivation of the effects of F-Met-Leu-Phe and leukotriene B4 on calcium mobilization in rabbit neutrophils |
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| Authors: | R I Sha'afi T F Molski P Borgeat P H Naccache |
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| Institution: | 1. Department of Physiology University of Connecticut Health Center Farmington, CT 06032 USA;2. Department of Pathology University of Connecticut Health Center Farmington, CT 06032 USA;3. Centre de Recherches en Endocrinologie Moleculaire Le Centre Hospitalier de l''Universite Laval Sainte-Foy, Quebec, Canada |
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| Abstract: | Preincubation of rabbit neutrophils with the synthetic chemotactic factor f-Met-Leu-Phe has been found to diminish the ability of these cells to mobilize calcium upon subsequent stimulation by f-Met-Leu-Phe or by leukotriene B4. The preexposure of the neutrophils to leukotriene B4 on the other hand results in a diminished subsequent response to itself but an unaltered response to f-Met-Leu-Phe. These results demonstrate that deactivation can be observed at the level of calcium mobilization, strengthen the postulated second messenger role of calcium in neutrophils and imply that neutrophil activation by chemotactic factors can bypass the arachidonic acid metabolic pathway. |
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| Keywords: | f-Met-Leu-Phe formyl-methionyl-leucyl-phenylalanine 5(S) 12(R)-dihydroxy-6 8 10 14(cis-trans-trans-cis)-eicosatetraenoic acid |
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