Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus |
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Authors: | Song-Yi Ha Hana Youn Chang-Seon Song Se Chan Kang Jong Jin Bae Hee Tae Kim Kwang Min Lee Tae Hoon Eom In Su Kim Jong Hwan Kwak |
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Institution: | 1. School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Republic of Korea 2. College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Republic of Korea 3. Department of Life Science, Gachon University, Sungnam, 461-701, Republic of Korea 4. Department of Oriental Pharmacy, Woosuk University, Jeonju, 565-701, Republic of Korea
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Abstract: | The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-β-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. The anti-influenza viral activity of isolates was evaluated using a plaque reduction assay against influenza A/NWS/33 (H1N1) virus. The compounds also were subjected to neuraminidase inhibition assay in influenza A/NWS/33 virus. Compounds 1–3 exhibited antiviral activity against an influenza A virus in vitro, and inhibited the neuraminidase activity at relatively high concentrations. |
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