Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene |
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| Authors: | D Samid E H Chang R M Friedman |
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| Affiliation: | 1. Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 USA;2. University Hositals of Cleveland, Cleveland, Ohio 44106 USA |
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| Abstract: | Mouse interferon (IFN) induced a phenotypic reversion in RS 485, a clonal line of NIH 3T3 oncogenically transformed by a human c-Ha-rasl gene activated by Ha-MuSV long terminal repeats (LTRs). Transfected c-Ha-ras DNA, unchanged in quantity and distribution, as compared to the parental RS 485 transformed cells, was still present in these revertants; however, there was a significant reduction in the amount of c-Ha-ras specific mRNA and of c-Ha-ras specified p21 protein. |
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| Keywords: | U 44069 15S-hydroxy-9α,11α-(epoxymethano) prosta-5Z,13E-dienoic acid U 46619 15S-hydroxy-11α,9α-(epoxymethano) prosta-5Z,13E-dienoic acid EP-092 (±)5-endo-(6′-carboxyhex-2′Z′enyl)-6-exo-{1″-[N-(phenylthiocarbamoyl)-hydrazono]-ethyl}-bicyclo[2,2,1] heptane |
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