| iTRAQ标记技术与差异蛋白质组学的生物标志物研究 |
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| 引用本文： | 王林纤,戴勇,涂植光.iTRAQ标记技术与差异蛋白质组学的生物标志物研究[J].生命的化学,2010(1). |
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| 作者姓名： | 王林纤 戴勇 涂植光 |
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| 作者单位： | 重庆医科大学;临床检验诊断学省部共建教育部重点实验室;深圳市人民医院;暨南大学第二临床医学院; |
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| 摘 要： | 结合多维液相色谱和串联质谱分析,iTRAQ技术已成为差异蛋白质组学定量研究的主要工具之一。而寻找和发现区别于正常生理状态下的疾病特异表达蛋白质,有利于阐明疾病的发病机理,对疾病的预防、诊断、预后和疗效监测具有重要作用,并有助于用作新靶点来开发临床治疗药物。本文重点就该技术在医学领域中进行差异蛋白质组分析并寻找标记蛋白质的研究进行综述。
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| 关 键 词： | iTRAQ 差异蛋白质组分析 蛋白质标记 |
iTRAQ labeling and biomarker discovery in comparative proteomic studies |
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| Lin-Qian Wang,Yong Dai,Zhi-Guang Tu Key laboratory of Laboratory Medical Diagnostics,Ministry of Education,Chongqing Medical University,Chongqing ,China,The Second Clinical Medical College,Jinan University,Shenzhen People\'s Hospital,Shenzhen.iTRAQ labeling and biomarker discovery in comparative proteomic studies[J].Chemistry of Life,2010(1). |
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| Authors: | Lin-Qian Wang Yong Dai Zhi-Guang Tu Key laboratory of Laboratory Medical Diagnostics Ministry of Education Chongqing Medical University Chongqing China The Second Clinical Medical College Jinan University Shenzhen People\'s Hospital Shenzhen |
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| Institution: | Lin-Qian Wang1,Yong Dai2,Zhi-Guang Tu1 1Key laboratory of Laboratory Medical Diagnostics,Ministry of Education,Chongqing Medical University,Chongqing 400016,China,2The Second Clinical Medical College,Jinan University,Shenzhen People\'s Hospital,Shenzhen 518020 |
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| Abstract: | Combined with multi-dimensional liquid chromatography and tandem mass spectrometry,isobaric tags for relative and absolute quantitation (iTRAQ) has been one of the main technologies for quantitatively comparative proteomic study.Search and discovery for potential disease-specific biomarkers differentiating from physiological processes can assist to elucidate pathogenesis and facilitate the prevention,diagnosis,prognosis and treatment of diseases,as well as to develop new drug targets for clinical use.Herein... |
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| Keywords: | isobaric tags for relative and absolute quantitation (iTRAQ) quantitatively comparative proteomic biomarker |
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