Genetical feedback repression. I. Single locus models |
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Authors: | J Tiwari A Fraser R Beckman |
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Institution: | Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, U.S.A. |
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Abstract: | The process of genetical feedback-repression analogous to the Jacob-Monod system has been simulated by digital computer modelling, allowing inclusion of stochastic variation of the components. In the absence of stochastic variability, the model shows a damped oscillation over a wide range of specifications. Inclusion of stochastic variation results in the model maintaining oscillations which, if summed over several independent genetical feedback-repression loops, results in a regular oscillation. |
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