Gene expression variation increase in trisomy 21 tissues |
| |
Authors: | Ching Yu Chou Li Yu Liu Chien Yu Chen Cheng Hsien Tsai Hsiao Lin Hwa Li Yun Chang Yi Shing Lin Fon Jou Hsieh |
| |
Institution: | 1. Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan 2. Department of Agronomy, Biometry Division, National Taiwan University, Taipei, Taiwan 3. Department of Life Science, National Taiwan University, Taipei, Taiwan 4. Department of Bio-industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan 5. Department of Paediatrics, National Taiwan University Hospital, Yunlin Branch, Douliou, Taiwan 6. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan 7. Welgene Biotech. Co., Ltd, 10F-5, No. 3 Yuan-Qu Street, NanGang Business Park, NanGang, Taipei, Taiwan 8. Center for Systems Biology and Bioinformatics, National Taiwan University, Taipei, Taiwan
|
| |
Abstract: | Congenital development disorders with variable severity occur in trisomy 21. However, how these phenotypic abnormalities develop
with variations remains elusive. We hypothesize that the differences in euploid gene expression variation among trisomy 21
tissues are caused by the presence of an extra copy of chromosome 21 and may contribute to the phenotypic variations in Down
syndrome. We used DNA microarray to measure the differences in gene expression variance between four human trisomy 21 and
six euploid amniocytes. The three publicly available data sets of fetal brains, adult brains, and fetal hearts were also analyzed.
The numbers of euploid genes with greater variance were significantly higher in all four kinds of trisomy 21 tissues (p < 0.01) than in the corresponding euploid tissues. Seventeen euploid genes with significantly different variance between
trisomy 21 and euploid amniocytes were found using the F test. In summary, there is a set of euploid genes that shows greater variance of expression in human trisomy 21 tissues than
in euploid tissues. This change may contribute to producing the variable phenotypic abnormalities observed in Down syndrome. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|