Brachyury regulatory region active in embryonal carcinoma P19 cells |
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Authors: | Yamaguchi H Kitagawa Y Miki K |
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Institution: | Graduate Program for Biochemical Regulation, Graduate School of Bioagricultural Sciences, Nagoya University, Japan. |
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Abstract: | Brachyury (T) is involved in mesoderm induction during early mouse development. We analyzed the region regulating expression of T in embryonal carcinoma P19 cells, which differentiate into mesoderm derivatives in vitro. Transfection of plasmids encoding reporter genes under the control of the 5'-flanking region showed positive regulatory elements between -298 and -129 bp are responsible for driving T expression in mesodermal cells. |
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