首页 | 本学科首页   官方微博 | 高级检索  
     


Interactive effects of intracisternal oxytocin and other centrally active substances on colonic temperatures of mice
Authors:G A Mason  J D Caldwell  D A Stanley  O L Hatley  A J Prange  C A Pedersen
Affiliation:1. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam;2. Hsinchu Branch, Livestock Research Institute, Council of Agriculture, Miaoli County 36841, Taiwan;3. Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan;1. Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, People’s Republic of China;2. State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen Research Institute of The Hong Kong Polytechnic University, Shenzhen 518057, People’s Republic of China;1. Hôpital Henri Mondor, Service de Dermatologie, APHP, Créteil, France;2. EpiDermE, Université de Paris Est Créteil, Val de Marne, France;3. Hôpital Saint Louis, Service de Dermatologie, APHP, Paris, France;4. Institut national de la santé et de la recherche médicale, Centre d''Investigation Clinique, Créteil, France;5. Service de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares, Hôpital Cochin, APHP-Centre Université de Paris, Paris;6. Université de Paris, Paris, France;7. Sorbonne Université, Faculté de Médecine, Hôpital Tenon, Service de Dermatologie, APHP, Paris, France;8. Médecine Interne, Hôpital Foch, Service de médecine Interne, Suresnes, France;9. Service de Dermatologie, Hôpital Cochin, APHP-Centre Université de Paris, Paris, France;1. Department of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, P.O. Box 17011, Doornfontein Campus, Johannesburg, South Africa;2. Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, Pretoria, South Africa;3. DST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa;4. Department of Consumer and Food Sciences, University of Pretoria, Hatfield, Pretoria, South Africa;1. College of Agriculture, Ningxia University, Yinchuan 750021, China;2. State Key Laboratory Cultivation Base for Northwest Degraded Ecosystem Recovery and Reconstruction, Yinchuan 750021, China
Abstract:Oxytocin (OXY) administered intracisternally to adult male mice produced a significant dose-related (1-4 micrograms) increase in colonic temperatures at an ambient temperature of 25 degrees C. The maximal rise in temperature occurred 30 min after administration of the peptide. The interactive effects on colonic temperature of central OXY with equimolar amounts of neurotensin, bombesin or beta-endorphin or of 2 2 mg/kg of chlorpromazine were investigated. OXY significantly antagonized the hypothermia produced by all of these substances. Pretreatment of mice with haloperidol or naloxone failed to prevent OXY-induced hyperthermia. The hyperthermic action of OXY and the interactive effects of OXY with other peptides on thermoregulation may be physiologically significant during parturition and lactation.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号