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Immunization with cellulose-immobilized antigens. The development of A. E. Gurvitch concept |
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| Authors: | Liashchuk A M Lunin V G Kariagina A S Lavrova N V Rodionova I V Kormilitsina M I Meshcheriakova I S Verkhovskaia L V Naroditskiĭ B S Gintsburg A L |
| Abstract: | A highly purified TUL4-CBD chimeric protein was obtained by one stage purification method. TUL4-CBD protein consists of TUL4 Francisella tularensis mature peptide sequence, Gly-Ser spacer and cellulose binding domain (CBD) of Anaerocellum thermophilum. The TUL4-CBD protein was shown to induce production of specific antibodies to TUL4 protein in laboratory animals. |
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