Biosynthesis of the carbohydrate portions of immunoglobulin M |
| |
| Authors: | R M E Parkhouse and Fritz Melchers |
| |
| Institution: | Department of Chemical Pathology, St George''s Hospital Medical School, London S.W.1, U.K. |
| |
| Abstract: | 1. Alkaline-earth-metal cations at low concentrations form soluble complexes with bovine caseins. The relative order of binding capacities is: Mg(2+)>Ca(2+)>Ba(2+)>Sr(2+). 2. The cations interact with both free ionized carboxyl groups of aspartic acid and glutamic acid and with monoester phosphate groups covalently bound to serine and threonine; at low concentrations of the cations interactions are predominantly with the phosphate groups. 3. The order of binding capacities for purified components of the casein complex is: alpha(s1)-casein>beta-casein>kappa-casein. |
| |
| Keywords: | |
|
|
