Mitochondria: Biological roles in platelet physiology and pathology |
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| Institution: | 1. Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil;2. Laboratório de Inflamação e Metabolismo, INBEB, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil;1. Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine, University of Pennsylvania, Philadelphia, PA;2. Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA;3. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;1. “L. Sacco” Department of Biomedical and Clinical Sciences, Laboratory of Maternal-Fetal Translational Research “Giorgio Pardi”, Università degli Studi di Milano, via G.B. Grassi 74, 20157 Milano, Italy;2. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via F. Sforza 35, 20122 Milano, Italy;3. Department of Mother and Child, Luigi Sacco Hospital, via G.B. Grassi 74, 20157 Milano, Italy;1. 3rd Department of Cardiology, Ippokrateio Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Institute of Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt/Main, Germany;3. German Center of Cardiovascular Research (DZHK), Frankfurt/Main, Germany;4. Department of Cardiology, Goethe University Frankfurt, Frankfurt/Main, Germany;5. Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece;1. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China;2. Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin 300384, China;3. Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China;4. Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin 300072, China;5. Wenzhou Safety (Emergency) Institute, Tianjin University, 325000, Wenzhou, China;6. National Institute of Metrology, Beijing 100029, China;7. Tianjin Institute of Medical & Pharmaceutical Sciences, Tianjin 300070, China;8. Hebei Research Center for Geoanalysis, Hebei 071000, China;9. Population Health Science Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE4 5PL, UK;1. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l''Université Laval, Département de Microbiologie et Immunologie, Quebec, QC, Canada;2. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l''Université Laval, Département de Psychiatrie et Neurosciences, Quebec, QC, Canada;3. Département de Biologie, Université Laval, Quebec, QC, Canada;4. Department of Chemistry, University of Washington, Seattle, WA;5. Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 7275, Centre National de la Recherche Scientifique-Université Nice Sophia Antipolis, Valbonne, France;6. Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom;7. Etablissement Français du Sang Auvergne-Loire and Université de Lyon, Saint-Etienne, France;8. Division of Rheumatology, Immunology and Allergy, Brigham and Women''s Hospital, and Division of Immunology, Boston Children''s Hospital, Harvard Medical School, Boston, MA;9. Research and Development, Héma-Québec, Quebec, QC, Canada;10. The Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael''s Hospital, Toronto, ON, Canada |
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| Abstract: | Mitochondria are key regulators of cellular energy and redox metabolism, also playing a central role in cell signaling and death pathways. A number of processes occur within mitochondria, including redox-dependent ATP synthesis by oxidative phosphorylation and reactive oxygen species production. Mitochondrial permeability transition is a reversible process that may lead to cell death and is regulated by calcium and reactive oxygen species. Functional mitochondria are present in platelets, and evidence has demonstrated the direct involvement of these organelles in cellular ATP production, redox balance, as well as in platelet activation and apoptosis. Here, we review aspects of platelet physiology in which mitochondria are involved, as well as assess their function as new tools for studying a number of human diseases. |
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| Keywords: | Mitochondria Platelet Hemostasis Apoptosis Disease |
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