Proliferating cell unclear antigen-associated factor (PAF15): A novel oncogene |
| |
| Institution: | 1. IRCCS S.D.N., Via Gianturco 113, 80143 Naples, Italy;2. Department of Cardiac Surgery, IRCCS Policlinico San Donato Milanese, Milan, Italy;3. Department of Translational Medical Sciences, Federico II University, Naples, Italy;4. Sezione Biochimica Clinica e Medicina Molecolare Clinica, Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli Studi di Palermo, Italy;5. Sezione di Patologia Generale, Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli Studi di Palermo, Italy;6. Department of Cardiology and Cardiac Surgery, University Hospital “Scuola Medica Salernitana”, Salerno, Italy;7. Department of Emergency and Cardiology, “S. Antonio” Community Hospital, San Daniele del Friuli (UD), Italy;8. Interdisciplinary Department of Medicine, Endocrinology and Metabolic Diseases, University of Bari, Italy;9. Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy;10. Department of Neurological Sciences, Federico II University, Naples, Italy;11. Department of Experimental Medicine, “Sapienza” University of Rome, Italy;12. Interdisciplinary Research Centre in Biomedical Materials (CRIB), University of Naples, Naples, Italy |
| |
| Abstract: | Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys15 and Lys24. Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival. Ectopic expression of PAF15 in mouse fibroblasts increases colony formation and tumourigenicity. PAF15 is aberrantly increased in various human malignancies with poor prognosis. Collectively, PAF15 may contribute to carcinogenesis and represents one of the potential therapeutic targets in the treatment of cancer. |
| |
| Keywords: | PCNA associated factor PAF15 DNA replication and DNA repair Cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
