Changes in the afferent activity of the vagus nerve and the rectal temperature in rats following Escherichia coli endotoxin administration] |
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| Authors: | V I Lapsha T M Lukashenko L N Utkina V N Gurin |
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| Affiliation: | Institute of Physiology, National Acad. Sci., Minsk, 220072, Akademicheskaya St., 28, Belarus. |
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| Abstract: | In anaesthetised rats, i.p. administration of the Echerichia coli lipopolysaccharide in doses 5 mcg/kg (LPS) increased afferent activity of the cervical vagus, whereas 100 and 1000 mcg/kg doses inhibited the afferent discharges. Pyrogen-free saline (PFS) did not alter the activity. Rectal temperature (RT) was decreased by the PFS and by large doses of the LPS. Sodium salicylate administration prevented the effects. |
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