Design and <Emphasis Type="Italic">In Vitro</Emphasis> Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels |
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Authors: | Xinsheng Peng Xinguo Wen Xin Pan Rongchang Wang Bao Chen Chuanbin Wu |
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Institution: | (1) School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, China;(2) School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, 523808, China; |
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Abstract: | The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin
using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed
based on the ternary phase diagram of the MO–PG–water system, and their internal structures were confirmed by polarizing light
microscopy (PLM) and small-angle X-ray scattering (SAXS). Release results showed the cubic phase gels could provide a sustained
system for capsaicin, while the initial water content in the gels was the major factor affecting the release rate. Release
kinetics was determined to fit Higuchi’s square-root equation indicating that the release was under diffusion control. The
calculated diffusion exponent showed the release from cubic phase gels was anomalous transport. The unique structure of the
cubic phases, capsaicin distributed in the lipid bilayers, and cubic phase gel swelling contributed to the release mechanism.
The cubic phase gel may be an interesting application for transdermal delivery system of capsaicin in alleviating the post-incision
pain. |
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Keywords: | |
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