Sequence-based identification of interface residues by an integrative profile combining hydrophobic and evolutionary information |
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Authors: | Peng Chen Jinyan Li |
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Affiliation: | (1) Bioinformatics Research Center, School of Computer Engineering, Nanyang Technological University, 639798, Singapore |
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Abstract: | Background Protein-protein interactions play essential roles in protein function determination and drug design. Numerous methods have been proposed to recognize their interaction sites, however, only a small proportion of protein complexes have been successfully resolved due to the high cost. Therefore, it is important to improve the performance for predicting protein interaction sites based on primary sequence alone. |
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