Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells |
| |
| Authors: | McHugh R S Shevach E M Thornton A M |
| |
| Affiliation: | Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |
| |
| Abstract: | CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
