Effects of N-nitrosopiperidine substitutions on mutagenicity in Drosophila melanogaster. |
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Authors: | C E Nix B Brewen R Wilkerson W Lijinsky J L Epler |
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Institution: | 1. Zentralinstitut für Genetik und Kulturpflanzenforschung der A.d.W. der D.D.R, 4325 Gatersleben German Democratic Republic;2. Department of General Genetics, University of Uppsala S-750 007 Uppsala 7 Sweden |
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Abstract: | N-Nitrosopiperidine (NP) and various derivatives were fed to Drosophila melanogaster males over a wide concentration range in order to assess their mutagenic potency in the induction of X-linked recessive lethals and chromosome loss. NP was effective in inducing lethals, as were its halogen and methyl-substituted derivatives, with the exception of 2,6-dimethyl NP. (Methyl substitutions at the alpha carbon atoms reduce or eliminate mutagenic activity.) Substitution of halogen groups on the piperidine ring enhanced the mutagenic activity, with the 3-chloro compound being the most mutagenic. In contrast, substitutions with a hydroxyl, carboxyl, or keto group resulted in a loss of mutagenicity. None of the compounds tested increased the frequency of chromosome loss or breakage in mature sperm. |
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