Chorionic gonadotropin-like proteins in the obplacental giant cells of the rabbit |
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Authors: | C Gründker M Hrabé de Angelis C Kirchner |
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Institution: | (1) Institute of Anatomy, School of Medicine, 2nd University of Naples, Via L. Armanni 5, I-80138 Naples, Italy |
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Abstract: | Diabetes mellitus was induced in 40 male C57BL6 mice by injection of a low dose of streptozocin (45 mg/kg body weight) on 5 consecutive days. Twenty four of the mice were immunosuppressed by administration of 1.5 mg FK506/kg body weight daily for 10, 15, 18 and 24 days. Administration of FK506 almost completely inhibited the streptozocin-induced islet damage, and consequently glycaemia remained normal. In FK506-treated animals any inflammatory infiltrate was very sparse and was limited to the vascular pole of the islets. Immunocytochemical results demonstrated that infiltrating cells were Ia-immunoreactive, but were not activated. Ultrastructural observations confirmed the absence of B cell necrosis and degranulation in FK506-treated mice; the few infiltrating elements encountered did not contain phagocytic vesicles or show other signs of activation. |
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Keywords: | Pancreatic islet B cell Streptozocin Type 1 diabetes Immunosuppression FK506 Mouse C57BL6 |
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