Quercetin inhibits hexose transport in a human diploid fibroblast |
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Authors: | Donald W Salter Susan Custead-Jones John S Cook |
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Institution: | (1) University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, 37830 Oak Ridge, Tennessee;(2) Biology Division, Oak Ridge National Laboratory, 37830 Oak Ridge, Tennessee;(3) Present address: Department of Microbiology, University of Illinois, 61801 Urbana, Illinois |
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Abstract: | Summary The flavonol quercetin, a phloretin analog, inhibits transport of 2-deoxyglucose and 3-O-methylglucose in a cultured human diploid fibroblast. This inhibition is related to transport itself and not to the reported effects of flavonoids on membrane-bound ATPases. From concentration-inhibition curves at several pH's we conclude that uncharged (acid) quercetin (pK=7.65) is the inhibitory form of the molecule (K
I
=10 m). Quercetin, unlike phloretin, is rapidly degraded in 0.1n NaOH; the degradation products are weakly inhibitory to hexose transport. |
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