Association of IL-6 − 174G > C and − 572C > G polymorphisms with risk of young ischemic stroke patients |
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Authors: | Xuan Yang Lei Feng Changjiang Li Yu Li |
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Affiliation: | 1. Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266000, China;2. Diagnostic Imaging Division, Qingdao Municipal Hospital, Qingdao 266000, China;3. Intensive Care Unit, Qingdao Central Hospital, Qingdao 266000, China;4. Zibo Municipal Hospital Authorities Internal Medicine, Zibo 255000, China |
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Abstract: | AimTo investigate the association between interleukin-6 (IL-6) − 174G > C and − 572C > G polymorphisms and risk for ischemic stroke (IS) in young patients.MethodsWe genotyped IL-6 − 174G > C and − 572C > G in a case–control study of 430 young IS patients and 461 control subjects. An unconditional multiple logistical regression model was used to calculate the effects of IL-6 − 174G > C and − 572C > G polymorphisms on IS risk.ResultsHigher body mass index, diabetes, hypertension, obesity, and smoking were associated with risk of ischemic stroke. Multivariate regression analyses showed that subjects carrying the − 174CC genotype (OR = 1.69, 95% CI = 1.16–2.57) and C allele (OR = 1.37, 95% CI = 1.09–1.67) had a small but significant increased risk of IS. Similarly, those carrying the − 572GG genotype (OR = 2.12, 95% CI = 1.18–3.82) and G allele (OR = 1.43, 95% CI = 1.14–1.83) had a moderate increased risk of IS. We found the − 174G > C and − 572C > G polymorphisms interact with hypertension and obesity.ConclusionOur results suggest that polymorphisms in IL-6 − 174G > C and − 572C > G are associated with IS risk in young patients, and that these polymorphisms interact with hypertension, obesity and etiologic subtypes. These findings could be helpful in identifying individuals at increased risk for developing IS. |
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Keywords: | IL-6, interleukin-6 IS, ischemic stroke EDTA, ethylenediaminetetra-acetic acid DNA, deoxyribonucleic acid PCR, polymerase chain reaction CI, confidence interval 95% OR, odds ratio SD, standard deviation HWE, Hardy&ndash Weinberg equilibrium BMI, body mass index TC, total cholesterol TG, triglycerides HDL-C, high density lipoprotein cholesterol LDL-C, low density lipoprotein cholesterol SPSS, Statistical Package for Social Science TOAST classification, Acute Stroke Treatment classification |
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