Matrix metalloproteinases and their role in psoriasis |
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| Authors: | Alexandre Mezentsev Alexander Nikolaev Sergey Bruskin |
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| Affiliation: | Vavilov Institute of General Genetics RAS, Gubkina str., Bld. 3, 119991 Moscow, Russia |
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| Abstract: | This review summarizes the contribution of matrix metalloproteinases to the pathogenesis of psoriasis. In psoriasis, matrix metalloproteinases are involved in the structural changes of the epidermis via the modification of intracellular contacts and the composition of the extracellular matrix, promoting angiogenesis in the dermal blood vessels and the infiltration of immune cells. Moreover, some matrix metalloproteinases become differentially expressed during the disease eruption and their expression correlates with the clinical score. A separate section of the review is dedicated to the pharmacological approaches that are used to control matrix metalloproteinases, such as oral metalloproteinase inhibitors, such as azasugars and phosphonamides. |
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| Keywords: | MMPs, matrix metalloproteinases MMPI, matrix metalloproteinases inhibitors ECM, extracellular matrix TIMPs, tissue inhibitor of metalloproteinase BM, basal membrane PBMC, peripheral blood mononuclear cells FBAT, family-based association test HB-EGF, heparin-binding epidermal growth factor HB-GEF, heparin -binding EGF-like growth factor uPAR, urokinase receptor |
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