The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas |
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| Authors: | Vanni Caruso,Maria G. Hä gglundLuca Badiali,Sonchita BagchiSahar Roshanbin,Tauseef AhmadHelgi B. Schiö th,Robert Fredriksson |
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| Affiliation: | Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden |
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| Abstract: | The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption. |
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| Keywords: | Cpu, Caudate putamen Pir, piriform cortex Tu, olfactory tubercle Acb, accumbens nucleus VP, ventral pallidum LPO, lateral preoptic area CA1-2-3, Cornu Ammonis 1-2-3 DG, dentate gyrus ARC, arcuate hypothalamic nucleus DM, dorsomedial VMHDM, VMHC, VMHVL, ventral medial LH, lateral hypothalamic nucleus Pe, Perifornical nucleus ACo, anterior cortical amygdaloid nucleus BMA, basomedial BLA, basolateral anterior BLV, basolateral ventral amygdaloid nucleus SNL SNR and SNC, substantia nigra lateral, reticulata and compact VTA, ventral tegmental area ML, medial mammillary nucleus RMC, red magnocell nucleus Sim, simple lobule (4 & 5 Cb), 4th/5th cerebellar lobules pcuf, preculminate fissure 3Cb, 3rd cerebellar lobule |
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