Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome |
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| Authors: | Qiuming Gong Matthew R. StumpZhengfeng Zhou |
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| Affiliation: | Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA |
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| Abstract: | |
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| Keywords: | CHX, cycloheximide EJC, exon junction complex hERG, human ether-a-go-go-related gene HPH, hygromycin B phosphotransferase LQT2, long QT syndrome type 2 MO, morpholino oligonucleotide NMD, nonsense-mediated mRNA decay nt, nucleotide PTC, premature termination codon RPA, RNase protection assay shRNA, short hairpin RNA UPF1, up-frameshift protein 1 WT, wild-type |
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