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Therapeutic potentials of gene silencing by RNA interference: Principles,challenges, and new strategies

Authors:	Yan Deng Chi Chiu Wang Kwong Wai Choy Quan Du Jiao Chen Qin Wang Lu Li Tony Kwok Hung Chung Tao Tang

Institution:	1. Department of Obstetrics & Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China;2. Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China;3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China;4. Linyi City People''s Hospital Division Medical District Nursing Office, Linyi, China

Abstract:

Keywords:	AAV adenovirus-associated vectors AGO argonaute AGT angiotensinogen AMD age-related macular degeneration APP amyloid precursor protein AV adenovirus vectors BACE1 β-site APP cleavage enzyme 1 bFGF basic fibroblast growth factor CCR5RZ T cell CCR5 cytokine receptor CD cyclodextrins Clu clusterin FOXO1 forkhead box protein O1 GnT-V N-acetylglucosaminyltransferase V HAART highly active antiretroviral therapy Her2 human epidermal growth factor receptor 2 IFN interferon LV lentivirus vectors MID middle miRNA microRNA MMP-9 metallopeptidase 9 MRP1 multidrug resistance-associated protein-1 NOX NADPH oxidase PAZ Piwi&ndash Argonaute&ndash Zwille PCSK9 proprotein convertase subtilisin/kexin type 9 PDAC pancreatic ductal adenocarcinoma PDX-1 pancreatic duodenal homebox-1 PEG polyethylene glycol PEI polyethylenimine PIWI P-element induced wimpy testis PKR protein kinase receptor PVN paraventricular nucleus RISC RNA-induced silencing complex RNAi RNA interference RV retrovirus vector shRNA short hairpin RNA siRNA small interfering RNA TGFbetaR2 transforming growth factor-beta receptor 2 TLRs Toll-like receptors VEGF vascular endothelial growth factor XPO-5 Exportin-5
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