Ultrastructural localization of Cu, Zn-SOD in hepatocytes of patients with various liver diseases |
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| Authors: | T Saito H Shinzawa H Togashi H Wakabayashi K Ukai T Takahashi M Ishikawa M Dobashi Y Imai |
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| Affiliation: | Second Department of Internal Medicine, Yamagata University, School of Medicine, Japan. |
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| Abstract: | The ultrastructural localization of copper, zinc-superoxide dismutase (Cu, Zn-SOD) in the liver of patients with acute hepatitis, chronic hepatitis, liver cirrhosis and alcoholic fatty liver was studied by means of the indirect immunoperoxidase technique. In hepatocytes Cu, Zn-SOD was found to be localized in perinuclear cisternae, rough endoplasmic reticulum (rER), vesicles and Golgi apparatus. The Cu, Zn-SOD was also detected around the lipid droplets in hepatocytes as well as on the cytoplasmic membrane in cases of liver cirrhosis. These findings suggest that Cu, Zn-SOD is produced in the rER in hepatocytes and protects the cells from cellular injury caused by superoxide anion radical in various disorders of the liver. |
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