| 眼镜蛇毒对大鼠弓状核nNOS表达的影响 |
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| 引用本文： | 徐臣利,王丽发,熊克仁. 眼镜蛇毒对大鼠弓状核nNOS表达的影响[J]. 蛇志, 2010, 22(1): 12-14 |
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| 作者姓名： | 徐臣利 王丽发 熊克仁 |
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| 作者单位： | 皖南医学院解剖学教研室,安徽芜湖,241002 |
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| 摘 要： | 目的探讨眼镜蛇毒对大鼠弓状核神经元型一氧化氮合酶(neuronal nitric oxide synthase,nNOS)表达的影响。方法采用免疫组织化学方法分别显示眼镜蛇毒组、生理盐水组和正常对照组弓状核的nNOS表达。结果与生理盐水组和正常对照组相比,眼镜蛇毒组弓状核nNOS阳性神经元数量明显减少,细胞平均灰度值明显升高(P0.05)。结论眼镜蛇毒能够使大鼠弓状核nNOS表达降低。
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| 关 键 词： | 眼镜蛇毒 弓状核 神经元型一氧化氮合酶 一氧化氮 |
Effect of Naja naja atra Venmom on Expression of nNOS in ARC of Rats |
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| XU Chen-li,WANG Li-fa,XIONG Ke-ren. Effect of Naja naja atra Venmom on Expression of nNOS in ARC of Rats[J]. Journal of Snake, 2010, 22(1): 12-14 |
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| Authors: | XU Chen-li WANG Li-fa XIONG Ke-ren |
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| Affiliation: | (Department of Anatomy, Wannan Medical College, Wuhu, Anhui, 241002, China) |
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| Abstract: | Objective To investigate the effects of Naja naja atra venom on the expression of nNOS in ARC of rats. Methods The methods of immunohistochemistry technique were used to observe the expression of nNOS positive cells among Naja naja atra venom group, saline group and control group. Results The number of nNOS positive cells in ARC of Naja naja atra venom group were lower than that of saline and control groups and the celluar average op- tic density value of Naja naja atra venom group was higher than that of saline and control group（P〈 0.05）. Conclusion Naja naja atra venom could decrease the expression of nNOS in ARC of rats. |
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| Keywords: | Naja naja atra venom ARC nNOS NO |
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