Gangliosides of normal and neoplastic human melanocytes |
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Authors: | J M Carubia R K Yu L J Macala J M Kirkwood J M Varga |
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Affiliation: | 1. Department of Dermatology, Yale University School of Medicine 333 Cedar Street, New Haven, Connecticut 06510 USA;2. Department of Neurology, Yale University School of Medicine 333 Cedar Street, New Haven, Connecticut 06510 USA;3. Yale Comprehensive Cancer Center, Yale University School of Medicine 333 Cedar Street, New Haven, Connecticut 06510 USA |
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Abstract: | The major ganglioside component isolated from diploid human melanocytes is sialosyllactosylceramide (GM3 86-91% of total sialic acid). The corresponding disialo derivative (GD3) is found as a minor component (2-6% of total sialic acid) in the membranes of these cells. In human melanoma cells, grown in tissue culture, GD3 is the predominant ganglioside component (48-63% of total sialic acid). Withdrawal of TPA from the culture medium of normal melanocytes or addition of TPA to the medium of melanoma cells had no significant effect on GM3/GD3 ratios. We conclude that the difference between the composition of gangliosides is related to the normal vs transformed phenotypes of melanocytes. |
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