Trypanosoma cruzi: 4-aminopyrazolopyrimidine in the treatment of experimental Chagas' disease |
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Authors: | JoséLuis Avila Angela Avila Edgar Mun̄oz Héctor Monzón |
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Affiliation: | Instituto Nacional de Dermatología, Apartado 4043, Caracas 1010, Venezuela |
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Abstract: | An allopurinol metabolite, 4-aminopyrazolopyrimidine, was tested on two different strains of mice (NMRI-IVIC and C57Bl/6J) that had been infected 4 days earlier with the virulent Ya strain of Trypanosoma cruzi. Low doses of 4-aminopyrazolopyrimidine (0.125-0.500 mg/kg body wt/day) for 10 days induced a significant reduction in parasitemia (direct counts and subinoculation experiments) and increased survival time (without any evidence of toxicity) compared with untreated animals. When tested in vitro, 4-aminopyrazolopyrimidine was sixfold more active than allopurinol as a trypanostatic drug. The low therapeutic doses of 4-aminopyrazolopyrimidine suggest that this drug may be useful in the treatment of acute Chagas' disease. |
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Keywords: | Hemoflagellate Protozoa, parasitic Chagas' disease Allopurinol, 4-hydroxypyrazolopyrimidine (HPP) 4-aminopyrazolopyrimidine (APP) Chemotherapy |
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