New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L |
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Authors: | Chethankumar Mukunda Srinivas Leela |
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Institution: | Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India. |
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Abstract: | Turmerin is a protein from Turmeric (Curcuma longa L.) with a relative molecular mass of 14 kDa. The protein inhibits the enzymatic activity and neutralizes the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase A2 (NV-PLA2) of cobra (Naja naja) venom at a 1:2.5 molar ratio of NV-PLA2:Turmerin. A Lineweaver-Burk plot indicates that Turmerin follows a linear mixed type of inhibition. |
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