Interferon‐α curbs production of interleukin‐22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi |
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Authors: | Anika Berner Malte Bachmann Josef Pfeilschifter Peter Kraiczy Heiko Mühl |
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Institution: | 1. Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe‐University Frankfurt, Frankfurt am Main, Germany;2. Institute of Medical Microbiology and Infection Control, University Hospital Goethe‐University Frankfurt, Frankfurt am Main, Germany |
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Abstract: | Cytokine networks initiated by means of innate immunity are regarded as a major determinant of host defence in response to acute infection by bacteria including Borrelia burgdorferi. Herein, we demonstrate that interferon (IFN)‐α, either endogenously produced after exposure of cells to toll‐like receptor‐9‐activating CpG oligonucleotides or provided as recombinant cytokine, weakens activation of the anti‐bacterial interleukin (IL)‐1/IL‐22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi. As IFN‐α has been related to pathological dissemination of the spirochaete, data suggest an immunoregulatory role of type I IFN in this context that is able to significantly modify cytokine profiles thereby possibly determining early course of B. burgdorferi infection. |
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Keywords: | interleukin‐1 interleukin‐22 interferon‐α inflammation host defence immune response
Borrelia burgdorferi
peripheral blood mononuclear cells |
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