Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II |
| |
| Authors: | Gizak A Rakus D Kolodziej J Zabel M Ogorzalek A Dzugaj A |
| |
| Affiliation: | Department of Animal Physiology, Institute of Zoology, Wroclaw University, Poland. |
| |
| Abstract: | The localization of fructose-1,6-bisphosphatase (Fru-1,6-Pase EC 3.1.3.11) in human alveolar epithelium was determined immunohistochemically using a polyclonal antibody raised against the enzyme purified from human liver. The immunohistochemical analysis revealed that the Fru-1,6-Pase was localized in pneumocytes II and was absent in pneumocytes I. Hypothetically Fru-1,6-Pase participating in glucose-6-phosphate synthesis from noncarbohydrate precursors increases NADPH level which is used for surfactant synthesis and for glutathione redox cycle. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
