| Abstract: | The influences of 6-OHDA (150 mcg intraventricular, bilaterally) on the behaviour of Wistar rats with different resistance to sound-stress were studied. Reduction of reactivity, exploratory activity and learning deterioration after 6-OHDA administration were observed. The behavioural disturbances were more demonstrative in stress-resistant rats. Biochemical estimations showed that 6-OHDA induced a reduction of brain noradrenaline level in stress-resistant rats and a reduction of dopamine level in nonresistant animal. It is suggested that more demonstrative behavioural disturbances induced by 6-OHDA in stress-resistant rats are connected with deficit of brain noradrenaline. |
