Direct antimicrobial activities of PR-bombesin |
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Authors: | Li Jianxu Xu Xueqing Yu Haining Yang Hailong Huang Zhongxian Lai Ren |
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Institution: | Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. |
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Abstract: | PR-bombesin is a bombesin-like peptide derived from the skin of the Chinese red belly toad, Bombina maxima. The 8-residue segment of N-terminal of RP-bombesin, comprising four prolines and three basic residues, is extensively different from other bombesin-like peptides. Since sequence of Pro-Arg-Pro generally plays an important role in the antimicrobial activity of proline-rich antimicrobial peptides, the componential feature of PR-bombesin indicates that it may have antimicrobial activity. In this paper, we presented the first evidence that bombesin-like peptides possess direct antimicrobial activities as some neuropeptides. It was determined by CD spectroscopy that PR-bombesin adopted a combination of random coil and beta-sheet structure, suggesting RP-bombesin is a new member of antimicrobial peptides having beta structure but without disulfide bonds. Current results also supported that PR-bombesin plays a direct defensive role besides its neuro-endocrological functions. |
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Keywords: | PR-bombesin Antimicrobial Neuropeptide Defensive |
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