Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease |
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Authors: | Túnez Isaac Drucker-Colín René Jimena Ignacio Medina Francisco J Muñoz Maria del Carmen Peña José Montilla Pedro |
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Institution: | Departamento de Bioquímica y Biología Molecular, y, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain. fm2tufii@uco.es |
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Abstract: | An investigation was conducted on the effect of transcranial magnetic field stimulation (TMS) on the free radical production and neuronal cell loss produced by 3-nitropropionic acid in rats. The effects of 3-nitropropionic acid were evaluated by examining the following changes in: the quantity of hydroperoxides and total radical-trapping antioxidant potential (TRAP), lipid peroxidation products, protein carbonyl groups, reduced glutathione (GSH) content, glutathione peroxidase (GSH-Px), catalase and succinate dehydrogenase (SDH) activities; total nitrite and cell death morphological changes, quantification of neuronal loss and lactate dehydrogenase (LDH) levels]. Our results reveal that 3-nitropropionic acid induces oxidative and nitrosative stress in the striatum, prompts cell loss and also shows that TMS prevents the harmful effects induced by the acid. In conclusion, the results show the ability of TMS to modify neuronal response to 3-nitropropionic acid. |
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Keywords: | cell loss free radicals Huntington's disease 3-nitropropionic acid succinate dehydrogenase transcranial magnetic stimulation |
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