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PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization |
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| Authors: | Cheung Derek Hang-Cheong Kung Hsiang-Fu Huang Jun-Jian Shaw Pang-Chui |
| Affiliation: | a Biochemistry Programme, School of Life Sciences and Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China b Stanley Ho Centre for Emerging Infectious Diseases and School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China c Laboratory of Tumor and Molecular Biology, Beijing Institute of Biotechnology, Beijing, China |
| Abstract: | Telomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells. |
| Keywords: | PinX1 Telomerase recruitment Cell cycle Mitosis Immunofluorescence |
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