The effect of indomethacin on the biosynthesis and metabolism of prostaglandin F2α in man |
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Authors: | Alan R. Brash Matthew E. Conolly |
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Affiliation: | Department of Clinical Pharmacology Royal Postgraduate Medical School Hammersmith Hospital Du Cane Road London W12 OHS UK |
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Abstract: | Healthy volunteers received 60 μg of [8,10,10-2H3] PGF2α by intravenous infusion both before and during a course of treatment with indomethacin (200 mg/day). Excretion of deuterated 5α, 7α-dihydroxy-11-ketotetranor-prostane-1, 16-dioic acid in urine was quantified by GC-MS using a reverse stable isotope dilution procedure. Indomethacin was found to have no detectable effect on the metabolism of the labelled PGF2α whereas output of the endogenous metabolite was markedly reduced by the effect of the drug on prostaglandin biosynthesis. |
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