On the Origin of Thymic Lymphocytes |
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Authors: | TURPEN JAMES B; PETER VOLPE E; COHEN NICHOLAS |
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Institution: | Department of Biology, Tulane University New Orleans, Louisiana 70118
Department of Microbiology, University of Rochester School of Medicine and Dentistry Rochester, New York 14642 |
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Abstract: | In the leopard frog (Rana pipiens), thymic lymphocytes do notoriginate from blood-borne stem cells that migrate into thethymus anlage; rather they arise in situ from elements in thethymic rudiment itself. After thymic differentiation, the lymphocytes(or their descendants) leave the thymus and extensively seedthe peripheral lymphoid organs. Indeed, virtually all the lymphocytesin the spleen, kidney, and bone marrow are ontogenically derivedfrom thymic cells. In postmetamorphic life, the thymus representsan organ in which lymphopoiesis is genuinely self-sustaining.Throughout the juvenile life of the frog, there is no indicationof an inward afferent stream of cells entering the intact thymus. |
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