| 钒对人红细胞膜蛋白和膜脂质过氧化的影响 |
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| 引用本文： | 陈宝卫,白玉国,王夔,张伯彦. 钒对人红细胞膜蛋白和膜脂质过氧化的影响[J]. 中国生物化学与分子生物学报, 1997, 13(2): 231-234 |
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| 作者姓名： | 陈宝卫 白玉国 王夔 张伯彦 |
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| 作者单位： | 北京医科大学药学院无机教研室!北京，100083(陈宝卫，白玉国，王夔)，南京大学化学化工学院!南京，210093(张伯彦) |
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| 基金项目： | 国家自然科学基金!29471007 |
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| 摘 要： | 对钒酸根V（V）与红细胞膜相互作用研究表明V（V）使膜蛋白内源荧光淬灭（KD，37＝2．23，KD，20＝4．17）和膜巯基含量降低，但对膜脂质过氧化影响较小，提示V（V）主要与膜蛋白作用．与V（V）不同，V（V）与红细胞膜的作用虽使膜蛋白就基含量下降，但不显著，其主要作用是引起膜脂质过氧化．
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| 关 键 词： | 钒酸根 氧钒离子 膜蛋白 脂质过氧化 |
| 收稿时间： | 1997-04-20 |
The Effect of Vanadium on Protein and Lipid Peroxidation of Erythrocyte Membrane |
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| Bao-Wei,Bai Yu-Guo,Wang Kui. The Effect of Vanadium on Protein and Lipid Peroxidation of Erythrocyte Membrane[J]. Chinese Journal of Biochemistry and Molecular Biology, 1997, 13(2): 231-234 |
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| Authors: | Bao-Wei Bai Yu-Guo Wang Kui |
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| Affiliation: | (Department of Inorganic Chemistry, Beijing Medical University, Beijing 100083) Zhang Bo-Yan (School of Chemistry and Chemical Technology, Naming University, Nanjing 210093 |
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| Abstract: | The interaction of vanadyl and vanadate with erythrocyte membrane was studied. The incubation with vanadate led to the quenching of intrinsic fluorescence of membrane proteins (KD,37 = 2.23, KD,20 = 4.17 ) and the reduction of the thiol content, but the effect of lipid peroxidation was not significant. The results indicate that the main binding sites of vanadate are on membrane proteins. The behavior of vanadyl was different from that of vanadate, the decrease in the thiol content of erythrocytr membrane was much less than vanadate, but the lipid peroxidation was enhanced much more significantly. |
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| Keywords: | Vanadate Vanadyl Membrane protein Lipid peroxidation |
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