Permeability changes during cell fusion |
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Authors: | C A Pasternak K J Micklem |
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Institution: | (1) Department of Biochemistry, University of Oxford, OX1 3QU Oxford, England |
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Abstract: | Summary During Sendai virus-mediated fusion of mouse ascites cells, there is a loss of intracellular metabolites; at the same time accumulation from the medium is inhibited. This failure to maintain selective permeability does not occur at 0°C; it is unaffected by cytochalasin B, which inhibits fusion. It therefore represents a discrete, temperature-dependent event and may result from a weakening in membrane architecture necessary to achieve fusion. |
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