Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B. |
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| Authors: | P Laurin D Ferroud L Schio M Klich C Dupuis-Hamelin P Mauvais P Lassaigne A Bonnefoy B Musicki |
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| Affiliation: | Medicinal Chemistry, Hoechst Marion Roussel, Romainville, France. |
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| Abstract: | Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro. |
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