Synthesis and antibacterial activity of some new non-proteinogenic amino acids containing thiazole residues |
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Authors: | M. Stanchev T. Pajpanova E. Golovinsky |
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Affiliation: | Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia. |
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Abstract: | Some new thioamides and thiazoles have been synthesized using canavanine, S-cysteine, homo-S-cysteinesulfonamides and their N-omega aminoethylated derivatives as adducts in order to investigate the structure-antimicrobial activity relationships. The compounds showed substantial antibacterial activity in vitro against various gram-positive (Staphylococcus aureus, Bacillus cereus etc.) and gram-negative (Escherichia coli, Proteus vulgaris etc.) bacteria. These findings indicate that the presence of the thiazole residue is an essential factor for the antibacterial effect. |
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