Antifungal Distribution Into Cerebrospinal Fluid,Vitreous Humor,Bone, and Other Difficult Sites |
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Authors: | Noha S Eltoukhy Christopher W Crank |
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Institution: | 1.Department of Pharmacy,Rush University Medical Center,Chicago,USA;2.Chicago College of Pharmacy,Midwestern University,Downers Grove,USA |
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Abstract: | The incidence of invasive fungal infections continues to increase, especially in patients with immune dysfunction. Fungal
infections are often difficult to treat, requiring therapy for weeks or months to eradicate infection. Although fungal infections
of the central nervous system, eye, and bones occur less frequently than infections at other sites, it is necessary to assess
the utility of the currently available antifungal agents in treating these infections. Unfortunately, information regarding
drug distribution to these sites is often scarce and limited to a few animal studies or case reports. This review summarizes
information about commonly used antifungal agents and their penetration into the central nervous system, eye, and bone. |
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Keywords: | |
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