Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels |
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| Authors: | Yunkui Zhu Xiangde Liu C Magnus Sköld Hangjun Wang Tadashi Kohyama Fu-Qiang Wen Ronald F Ertl Stephen I Rennard |
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| Affiliation: | (1) University of Nebraska Medical Center, Omaha, Nebraska, USA;(2) Karolinska Hospital, Stockholm, Sweden;(3) Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; |
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| Abstract: | Background Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate production of matrix-degrading metalloproteinases by these cells in co-culture and to determine if neutrophil elastase could collaborate in the activation of these enzymes. Since co-cultures produce prostaglandin E2 (PGE2), the role of PGE2 in this process was also evaluated. |
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