Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |
| |
Authors: | D C Diamond B P Sleckman T Gregory L A Lasky J L Greenstein S J Burakoff |
| |
Affiliation: | Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115. |
| |
Abstract: | The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response. |
| |
Keywords: | |
|
|