Association study in eating disorders: TPH2 associates with anorexia nervosa and self‐induced vomiting |
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| Authors: | M. C. T. Slof‐Op ‘t Landt I. Meulenbelt M. Bartels E. Suchiman C. M. Middeldorp J. J. Houwing‐Duistermaat J. van Trier E. J. Onkenhout J. M. Vink C. E. M. van Beijsterveldt M. K. Brandys N. Sanders S. Zipfel W. Herzog B. Herpertz‐Dahlmann K. Klampfl C. Fleischhaker A. Zeeck M. de Zwaan S. Herpertz S. Ehrlich A. A. van Elburg R. A. H. Adan S. Scherag A. Hinney J. Hebebrand D. I. Boomsma E. F. van Furth P. E. Slagboom |
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| Affiliation: | 1. Center for Eating Disorders Ursula, Leidschendam;2. Department of Medical Statistics, Molecular Epidemiology Section, Leiden University Medical Centre, Leiden;3. Department of Biological Psychology, VU University, Amsterdam;4. De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam;5. Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden;6. Department of Psychiatry and Psychology, St Antonius Hospital, Utrecht;7. Emergis, Department of Eating Disorders, Goes;8. Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht;9. Altrecht Mental Health Institute, Rintveld Centre for Eating Disorders, Zeist, The Netherlands;10. Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital, Tübingen;11. Department of Psychosomatic and General Internal Medicine, University Medical Hospital, Heidelberg;12. Department of Child and Adolescent Psychiatry and Psychotherapy, Universit?tsklinikum Aachen, Aachen;13. Department of Child and Adolescent Psychiatry and Psychotherapy, Julius‐Maximilians University of Würzburg, Würzburg;14. Clinic and Day Clinic of Child and Adolescent Psychiatry and Psychotherapy, Albert Ludwigs‐University of Freiburg, Freiburg i. Br.;15. Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Freiburg;16. Department for Psychosomatic Medicine and Psychotherapy, University Erlangen‐Nuremberg, Erlangen;17. Clinic of Psychosomatic Medicine and Psychotherapy, LWL‐University Clinic, Ruhr‐University Bochum;18. Department of Child and Adolescent Psychiatry, Charité–Universit?tsmedizin Berlin, Berlin, Germany;19. Translational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany;20. Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands;21. Department of Child and Adolescent Psychiatry and Psychotherapy, LVR Klinkum Essen, University of Duisburg‐Essen, Essen, Germany |
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| Abstract: | Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self‐induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71–91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain‐derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P‐values < 0.05 from this initial study were then tested for replication in a meta‐analysis with two additional independent ED case–control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C‐allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08–1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28–2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16–1.64, P < 0.0003). The meta‐analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group. |
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| Keywords: | Anorexia nervosa candidate genes genetic association study TPH2 self‐induced vomiting |
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